The application of ITalent Virtual 2.0 and its evaluation in terms of the generation of disruptive innovations are presented in this article. A sample of 17 projects taken was selected for the fourth stage of said method, being evaluated through the litmus test and later by the binomial test. The type of research was experimental, with a post-test group design. The results obtained show that most of the projects evaluated are disruptive, proving the method’s effectiveness. This result is relevant because it validates a methodology that allows business incubators to have participants that generate disruptive innovations.