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Patent

ALAMBIQUE DE BAJA PRESION O VACIO PARCIAL Y DE CONDENSACION MEDIANTE GAS REFRIGERANTE IQ

( 2022-04-23)

Córdova Salas, PATRICIA

Consiste en un dispositivo para el tratamiento y la eliminación de bacterias en hidrocarburos combustibles cuya función es asegurar la pureza de dichos combustibles. La eliminación de las baterías se da a cabo de manera catalítica gracias a la aleación de la que está compuesta su parte interior y la interacción con la carcasa que lo contiene. Este dispositivo cuenta con la ventaja de tener efecto más intenso de eliminación de contaminación microbiológica que otras tecnologías. Se instala dentro de los tanques de almacenamiento y su reacción empieza cuando entre en contacto con el combustible.

Publication

Kuskaya: A training program for collaboration and innovation in global health IQ

( 2019-05-10)

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To solve increasingly complex global health problems, health professionals must collaborate with professionals in non-health-related fields. The Universidad Peruana Cayetano Heredia and University of Washington created the NIH-funded Kuskaya training program in response to the need for transformative global health training for talented graduates from all disciplines. Kuskaya is a 1-year, interdisciplinary training program that teaches Peruvian and US graduates critical skills related to public health research through the design and implementation of a collaborative research project in Peru. Between 2014 and 2018, the program has trained 33 fellows, of which one third were from non-health disciplines. The program is unique because it targets junior trainees from disciplines outside of the health field, the program’s curriculum is adapted to fit the fellows’ backgrounds and professional aspirations, and the structure of the program allows for collaboration within the cohort and encourages fellows to apply for additional funding and pursue advanced degrees.

Publication

Mapping the Evolutionary Space of SARS-CoV-2 Variants to Anticipate Emergence of Subvariants Resistant to COVID-19 Therapeutics

( 2024)

Chavez, Roberth Anthony Rojas

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Fili, Mohammad

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Han, Changze

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Rahman, Syed A.

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Bicar, Isaiah G. L.

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Gregory, Sullivan

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Helverson, Annika

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Hu, Guiping

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Darbro, Benjamin W.

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Das, Jishnu

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Brown, Grant D.

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Haim, Hillel

New sublineages of SARS-CoV-2 variants-of-concern (VOCs) continuously emerge with mutations in the spike glycoprotein. In most cases, the sublineage-defining mutations vary between the VOCs. It is unclear whether these differences reflect lineage-specific likelihoods for mutations at each spike position or the stochastic nature of their appearance. Here we show that SARS-CoV-2 lineages have distinct evolutionary spaces (a probabilistic definition of the sequence states that can be occupied by expanding virus subpopulations). This space can be accurately inferred from the patterns of amino acid variability at the whole-protein level. Robust networks of co-variable sites identify the highest-likelihood mutations in new VOC sublineages and predict remarkably well the emergence of subvariants with resistance mutations to COVID-19 therapeutics. Our studies reveal the contribution of low frequency variant patterns at heterologous sites across the protein to accurate prediction of the changes at each position of interest.We describe a systematic approach to identify "clues" that can predict the mutational profiles of SARS-CoV-2 subvariants at early stages after emergence of their parental lineages. We found that the likelihood for mutations at each position of spike is lineage-specific, and is estimated well by the mutational patterns at all positions of the protein. As examples, we apply the model to forecast emergence of resistance to the antibody therapeutics Bebtelovimab and Cilgavimab, which appeared in sublineages of VOCs BA.5 and BA.4, respectively. Emergence of these subvariants required changes in treatment protocols of COVID-19 patients. In both cases, the escape mutations were predicted well by the mutational profiles at all positions of spike at early time points after emergence of the parental VOCs. Accurate estimations of the imminent changes in SARS-CoV-2 lineages can contribute to design and selection of therapeutics that maintain their efficacy against future forms of this virus.

Publication

Exploring the adjustment to parasite pressure hypothesis: differences in uropygial gland volume and haemosporidian infection in palearctic and neotropical birds

( 2021)

Magallanes, Sergio

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Moller, Anders Pape

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Lujan-Vega, Charlene

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Fong, Esteban

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Vecco, Daniel

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Flores-Saavedra, Wendy

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Garcia-Longoriaa, Luz

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de Lope, Florentino

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Iannacone, Jose A.

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Marzal, Alfonso

Parasites are globally widespread pathogenic organisms, which impose important selective forces upon their hosts. Thus, in accordance with the Adjustment to parasite pressure hypothesis, it is expected that defenses among hosts vary relative to the selective pressure imposed by parasites. According to the latitudinal gradient in diversity, species richness and abundance of parasites peak near the equator. The uropygial gland is an important defensive exocrine gland against pathogens in birds. Size of the uropygial gland has been proposed to vary among species of birds because of divergent selection by pathogens on their hosts. Therefore, we should expect that bird species from the tropics should have relatively larger uropygial glands for their body size than species from higher latitudes. However, this hypothesis has not yet been explored. Here, we analyze the size of the uropygial gland of 1719 individual birds belonging to 36 bird species from 3 Neotropical (Peru) and 3 temperate areas (Spain). Relative uropygial gland volume was 12.52% larger in bird species from the tropics than from temperate areas. This finding is consistent with the relative size of this defensive organ being driven by selective pressures imposed by parasites. We also explored the potential role of this gland as a means of avoiding haemosporidian infection, showing that species with large uropygial glands for their body size tend to have lower mean prevalence of haemosporidian infection, regardless of their geographical origin. This result provides additional support for the assumption that secretions from the uropygial gland reduce the likelihood of becoming infected with haemosporidians.

Patent

PAILA PIROTUBULAR - ALETEADA PARA LA AGROINDUSTRIA RURAL DE PRODUCCION DE PANELA GRANULADA IQ

( 2021-12-29)

Saavedra García Zabaleta, Rafael

La invención está referida a un aparato, método y sistema, para la determinación puntual del bioparámetro temperatura; el cual se caracteriza por que cuenta con un dispositivo localizador de dichos puntos, que corresponden a la zona más prominente del área plantar del pie humano en el: hallux, la base del 1er metatarsiano, la base del 5to metatarsiano y el talón (según la fig. 4); de manera que se genera un informe con los datos, con la diferencias de dichos datos y una presunción y recomendaciones del estado de salud de la persona, para que sea sometido a un diagnóstico o una acción profiláctica.

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