Browsing by Type "Controlled Vocabulary for Resource Type Genres::texto::revista::artículo::artículo original"
  • Institution Publication
    19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: Maternal risk of Down syndrome and folate metabolism
    ( 2010-01-01)
    Mendes C.C.
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    Biselli J.M.
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    Zampieri B.L.
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    Goloni-Bertollo E.M.
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    Eberlin M.N.
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    Haddad R.
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    Riccio M.F.
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    Vannucchi H.
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    Carvalho V.M.
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    Pavarino-Bertelli E.C.
    Context and objective: Polymorphisms in genes involved in folate metabolism may modulate the maternal risk of Down syndrome (DS). This study evaluated the influence of a 19-base pair (bp) deletion polymorphism in intron-1 of the dihydrofolate reductase (DHFR) gene on the maternal risk of DS, and investigated the association between this polymorphism and variations in the concentrations of serum folate and plasma homocysteine (Hcy) and plasma methylmalonic acid (MMA). Design and setting: Analytical cross-sectional study carried out at Faculdade de Medicina de São José do Rio Preto (Famerp). Methods: 105 mothers of individuals with free trisomy of chromosome 21, and 184 control mothers were evaluated. Molecular analysis on the polymorphism was performed using the polymerase chain reaction (PCR) through differences in the sizes of fragments. Folate was quantified by means of chemiluminescence, and Hcy and MMA by means of liquid chromatography and sequential mass spectrometry. Results: There was no difference between the groups in relation to allele and genotype frequencies (P = 0.44; P = 0.69, respectively). The folate, Hcy and MMA concentrations did not differ significantly between the groups, in relation to genotypes (P > 0.05). Conclusions: The 19-bp deletion polymorphism of DHFR gene was not a maternal risk factor for DS and was not related to variations in the concentrations of serum folate and plasma Hcy and MMA in the study population.
  • Institution Publication
    2-oxazoline telechelic polymers: Synthesis and characterization
    ( 2025-01-01)
    Rueda J.C.
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    Honoresa H.G.
    New telechelic polymers functionalized with terminal ethyl xanthate or vinyl groups were synthesized via cationic ring-opening polymerization (CROP). The polymerization of 2-ethyl-2-oxazoline (Etoxa) and 2-methoxycarbonylethyl-2-oxazoline (Esteroxa) was initiated by 1,4-trans-dibromobutene in acetonitrile at 78 ℃, with termination using either potassium ethyl xanthate or 4-vinylbenzyl-piperazine. Structural characterization by1H and13C NMR and FTIR spectroscopy confirmed the telechelic architecture.1H NMR analysis revealed degrees of polymerization (DP) of 24–29 for ethyl xanthate-terminated polymers and 22–23 for vinyl-terminated polymers, consistent with theoretical values. The molar compositions of Etoxa and Esteroxa in all telechelic polymers matched the initial monomer feed ratios. End-group functionalization efficiency was quantified as follows: Ethyl xanthate-terminated polymers: 64%–82%, and vinyl-terminated polymers: 69% and 98% (for respective batches).
  • Institution Publication
    2CA-R2: A Hybrid MAC Protocol for Machine-Type Communications
    ( 2025-05-01)
    Javier-Alvarez S.
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    Hernandez-Duran P.
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    Lopez-Guerrero M.
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    Orozco-Barbosa L.
    Machine-to-machine (M2M) communications are becoming the most important factor shaping network traffic. However, traditional controls developed for human-generated traffic are not able to cope with new demands. Thus, hybrid MAC protocols have been proposed to make use of the combined advantages of contention and reservation. Most of them are based on a contention stage (where a variant of CSMA/CA or ALOHA is used) followed by a reservation stage (e.g., TDMA or FDMA). In this paper, we introduce 2CA-R2, a hybrid MAC protocol for M2M communications intended to be used in the device domain. What distinguishes this proposal is that the contention stage is controlled by a conflict–resolution algorithm known as Adaptive-2C. The protocol was evaluated using a model based on a Markov chain and computer simulations. Its performance was compared with DCF, the MAC technique used in IEEE802.11 standards. Our results show significant improvements over DCF in various metrics of network performance across different traffic situations. We also evaluated the time the protocol takes to resolve an access conflict, and we observed substantial improvements in the number of stations that can be served with the same network resource (in some cases, around a 40% improvement).
  • Institution Publication
    4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection
    ( 2025-02-07)
    de Lima I.L.
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    Cataldi T.R.
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    Brites C.
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    Labate M.T.V.
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    Vaz S.N.
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    Deminco F.
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    da Cunha G.S.
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    Labate C.A.
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    Eberlin M.N.
    Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sublineages, driving new and breakthrough infections globally over the past two years. In this study, we investigated for the first time the host salivary response of COVID-19 patients infected with Omicron variants (BA.1, BA.2, and BA.4/5) by using an untargeted four-dimensional data-independent acquisition (4D-DIA)-based proteomics approach. We identified 137 proteins whose abundance levels differed between the COVID-19 positive and negative groups. Salivary signatures were mainly enriched in ribosomal proteins, linked to mRNAviral translation, protein synthesis and processing, immune innate, and antiapoptotic signaling. The higher abundance of 14-3-3 proteins (YWHAG, YWHAQ, YWHAE, and SFN) in saliva, first reported here, may be associated with increased infectivity and improved viral replicative fitness. We also identified seven proteins (ACTN1, H2AC2, GSN, NDKA, CD109, GGH, and PCYOX) that yielded comprehension into Omicron infection and performed outstandingly in screening patients with COVID-19 in a hospital setting. This panel also presented an enhanced anti-COVID-19 and anti-inflammatory signature, providing insights into disease severity, supported by comparisons with other proteome data sets. The salivary signature provided valuable insights into the host’s response to SARS-CoV-2 Omicron infection, shedding light on the pathophysiology of COVID-19, particularly in cases associated with mild disease. It also underscores the potential clinical applications of saliva for disease screening in hospital settings. Data are available via ProteomeXchange with the identifier PXD054133.
  • Institution Publication
    A baseline for assessing the ecological integrity of Western Amazon rivers
    ( 2025-12-01)
    Anderson E.P.
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    Encalada A.C.
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    Couto T.B.A.
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    Couto T.B.A.
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    Beveridge C.F.
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    Herrera-R G.A.
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    Heilpern S.A.
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    Heilpern S.A.
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    Almeida R.M.
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    Cañas-Alva C.
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    Correa S.B.
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    de Souza L.S.
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    Duponchelle F.
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    Garcia-Davila C.
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    Goulding M.
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    López-Casas S.
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    Maldonado-Ocampo J.A.
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    Miranda-Chumacero G.
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    Montoya M.
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    Piland N.C.
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    Victoria-Lacy L.
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    Varese M.
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    Varese M.
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    Jenkins C.N.
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    Jenkins C.N.
    Amazon freshwater systems influence global hydroclimatic patterns, host unparalleled biological diversity, and support unique social-ecological systems. Rivers of the Western Amazon underpin this global importance with an outsized, underrecognized role at the Amazon Basin scale. Here we examined the status of several components—hydrology, sediments, freshwater fish biodiversity, and longitudinal river connectivity—that support the ecological integrity of Western Amazon rivers and their linkage to the greater Amazon Basin. Streamflow is largely driven by precipitation and the region supplies nearly all sediments delivered by the Amazon River to the Atlantic Ocean. The Western Amazon harbors 74% of the ichthyofauna of the entire Amazon Basin. Existing dams and road crossings have disrupted longitudinal river connectivity on several rivers. We estimated that 47.8 million people reside in the Amazon Basin, with more than half (58%) inhabiting the Western Amazon. This study helps establish a baseline for tracking change in Western Amazon river ecosystems.
  • Institution Publication
    A bibliometric analysis of sustainable development goals (SDGs): a review of progress, challenges, and opportunities
    ( 2024-05-01)
    Mishra M.
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    Mishra M.
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    Desul S.
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    Desul S.
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    Santos C.A.G.
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    Mishra S.K.
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    Kamal A.H.M.
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    Goswami S.
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    Kalumba A.M.
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    Biswal R.
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    da Silva R.M.
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    dos Santos C.A.C.
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    Baral K.
    The Sustainable Development Goals (SDGs) are a global appeal to protect the environment, combat climate change, eradicate poverty, and ensure access to a high quality of life and prosperity for all. The next decade is crucial for determining the planet’s direction in ensuring that populations can adapt to climate change. This study aims to investigate the progress, challenges, opportunities, trends, and prospects of the SDGs through a bibliometric analysis from 2015 to 2022, providing insight into the evolution and maturity of scientific research in the field. The Web of Science core collection citation database was used for the bibliometric analysis, which was conducted using VOSviewer and RStudio. We analyzed 12,176 articles written in English to evaluate the present state of progress, as well as the challenges and opportunities surrounding the SDGs. This study utilized a variety of methods to identify research hotspots, including analysis of keywords, productive researchers, and journals. In addition, we conducted a comprehensive literature review by utilizing the Web of Science database. The results show that 31% of SDG-related research productivity originates from the USA, China, and the UK, with an average citation per article of 15.06. A total of 45,345 authors around the world have contributed to the field of SDGs, and collaboration among authors is also quite high. The core research topics include SDGs, climate change, Agenda 2030, the circular economy, poverty, global health, governance, food security, sub-Saharan Africa, the Millennium Development Goals, universal health coverage, indicators, gender, and inequality. The insights gained from this analysis will be valuable for young researchers, practitioners, policymakers, and public officials as they seek to identify patterns and high-quality articles related to SDGs. By advancing our understanding of the subject, this research has the potential to inform and guide future efforts to promote sustainable development. The findings indicate a concentration of research and development on SDGs in developed countries rather than in developing and underdeveloped countries. Graphical abstract: (Figure presented.).
  • Institution Publication
    A bibliometric analysis of the Global Reporting Initiative (GRI): global trends in developed and developing countries
    ( 2024-03-01)
    Mougenot B.
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    Doussoulin J.P.
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    Doussoulin J.P.
    The growing concern about climate change necessitates the development of models for long-term measurements of the sustainability performance. The Global Reporting Initiative suggests a framework for sustainability reporting. This study intends to fill two gaps in the existing literature. On the one hand, it assesses the Global Reports Initiative's impact on academics. This article, on the other hand, will compare public policies aimed at a Global Reporting Initiative in rich and developing countries from 1999 to 2020. The above research utilizes bibliometric analysis via Biblioshiny and the Scopus publications database, as well as an online interface for Bibliometrix analysis. For studying the Global Reports Initiative literature, this method offers a viable alternative to traditional bibliometric analysis. This is one of the first studies to use a computer approach to examine the literary paths of the Global Reporting Initiative issue. Among the findings we can mention that, the most GRI inquiries were distributed by the "Journal of Cleaner Production." The most useful GRI creators are Clarkson PM., Azapagic A., and Milne MJ. The findings of this paper suggest that the composition of the GRI addresses one of the keys to global monetary advancement, particularly in developing countries, for the foreseeable future. Our paper indicates that the Global Reporting Initiative principles have a strong potential to handle these connected issues in managing and maintaining the environment by adapting developed-country experiences to developing-country challenges.
  • Institution Publication
    A bibliometric analysis of the Global Reporting Initiative (GRI): global trends in developed and developing countries
    ( 2024-03-01)
    Mougenot B.
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    Doussoulin J.P.
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    Doussoulin J.P.
    The growing concern about climate change necessitates the development of models for long-term measurements of the sustainability performance. The Global Reporting Initiative suggests a framework for sustainability reporting. This study intends to fill two gaps in the existing literature. On the one hand, it assesses the Global Reports Initiative's impact on academics. This article, on the other hand, will compare public policies aimed at a Global Reporting Initiative in rich and developing countries from 1999 to 2020. The above research utilizes bibliometric analysis via Biblioshiny and the Scopus publications database, as well as an online interface for Bibliometrix analysis. For studying the Global Reports Initiative literature, this method offers a viable alternative to traditional bibliometric analysis. This is one of the first studies to use a computer approach to examine the literary paths of the Global Reporting Initiative issue. Among the findings we can mention that, the most GRI inquiries were distributed by the "Journal of Cleaner Production." The most useful GRI creators are Clarkson PM., Azapagic A., and Milne MJ. The findings of this paper suggest that the composition of the GRI addresses one of the keys to global monetary advancement, particularly in developing countries, for the foreseeable future. Our paper indicates that the Global Reporting Initiative principles have a strong potential to handle these connected issues in managing and maintaining the environment by adapting developed-country experiences to developing-country challenges.
  • Institution Publication
    A bibliometric approach to worldwide scientific production of familial hypophosphataemic rickets in Scopus (2000–2022)
    ( 2025-12-01)
    Hernández-García F.
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    Hernández-García F.
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    Hernández-García F.
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    Gil-Peña H.
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    Gil-Peña H.
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    Gil-Peña H.
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    López J.M.
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    López J.M.
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    Fuente R.
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    Oro Carbajosa P.
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    Oro Carbajosa P.
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    Corrales-Reyes I.E.
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    Suárez J.R.
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    Suárez J.R.
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    Suárez J.R.
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    Suárez J.R.
    Background: Familial hypophosphatemic rickets are disabling conditions that negatively impact physical functioning, activities of daily living, mental health and social life. The most common cause of hypophosphatemic rickets is genetic factors, such as X-linked hypophosphatemia. The evaluation of the scientific application of familial hypophosphataemic rickets aids in understanding the research landscape, identifying opportunities for improvement, and promoting significant advancements in the understanding and treatment of this medical condition. This study aimed to characterize the worldwide scientific production of articles on familial hypophosphatemic rickets indexed in Scopus, through the analysis of publication growth rate, leading countries and journals, international collaboration networks, and predominant research keywords. Methods: An observational, descriptive, and cross-sectional study was conducted through a bibliometric analysis of the worldwide scientific production of familial hypophosphatemic rickets published in journals indexed in Scopus from 2000 to 2022. To retrieve the publications, Scopus was accessed on April 4, 2023, and an advanced search was performed using a filter by title, abstract and key words, source (journals), publication year, and type of article (article and review). The search terms used were extracted from the PubMed Medical Subject Headings (MeSH) related to the disease included in the MeSH catalog. Additionally, an analysis of co-occurrence between countries and keywords was carried out with VOSviewer software. Results: This study identified 1,269 articles on familial hypophosphatemic rickets (938 articles and 331 reviews). In total, 39,548 citations were received, with an H index of 95. The majority of the articles (76.9%) were published in high-impact journals according to quartile (Q), Q1 and Q2. Scientific production has shown a growing trend in recent years. The countries with the highest scientific production are the U.S., Japan, and the United Kingdom, considering that low- and middle-income countries contribute less to international scientific production. Among 1,858 author keywords, 109 met the inclusion threshold (≥ 6 occurrences) and were grouped into five thematic clusters related to genetics, treatment, pathophysiology, complications, and clinical manifestations. Recent research trends highlight increasing focus on burosumab, quality of life, and chronic complications in familial hypophosphatemic rickets. Conclusions: Scientific production has shown sustained growth in recent years. The U.S. solidifies itself as the country leading scientific production on familial hypophosphatemic rickets.
  • Institution Publication
    A cesium-iodide surface treatment for enhancement of negative electron affinity photocathode chemical robustness
    ( 2025-06-14)
    Levenson S.J.
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    Andorf M.B.
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    Reamon M.A.
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    Bazarov I.V.
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    Galdi A.
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    Zhu Q.
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    Hines M.A.
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    Encomendero J.
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    Protasenko V.V.
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    Jena D.
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    Jena D.
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    Jena D.
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    Xing H.G.
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    Xing H.G.
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    Xing H.G.
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    Maxson J.M.
    Photocathodes activated to negative electron affinity with a cesium-based activation layer, such as GaAs and GaN, can be used for generating spin-polarized electron beams, but their extreme sensitivity to chemical poisoning limits their operational lifetimes. This work demonstrates that applying and subsequently heating a cesium iodide (CsI) coating can produce a more durable activation layer lacking iodine, but rich in stable cesium suboxides (formal O oxidation state > − 2 ), which significantly extend the dark lifetimes of both GaAs and GaN photocathodes. Through x-ray photoelectron spectroscopy, we examine the stability and formation of these Cs suboxides, which exhibit remarkable resistance to chemical poisoning. Additionally, we investigate the subsequent surface quality using atomic force microscopy. Our findings show that CsI-based surface treatments not only prolong photocathode lifetime but also maintain high spin polarization, positioning this method as a promising approach for enhancing photocathode durability in demanding applications.
  • Institution Publication
    A Clustering Approach to Identify Risk Perception on Social Networks: A Study of Peruvian Children and Adolescents
    ( 2026-01-01)
    Pérez Vera Y.
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    Escobedo Quispe R.S.
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    Ramírez Santos P.A.
    The excessive and inappropriate use of the internet by children and young people increases their exposure to risky situations, especially since the COVID-19 pandemic. This study analyzes risky situations on social media among children and adolescents. The objective of this work was to identify the risks associated with the use of social media. A comparative analysis of five clustering algorithms was applied to a dataset developed by eBiz Latin America in collaboration with La Salle University of Arequipa and the Institute of Christian Schools of the De La Salle Brothers of the Bolivia-Peru district. Among the results, it was shown that children around 11 years old display a high prevalence of digital risk behaviors such as adding strangers, followed by pretending to be someone else; adults around 43 years old exhibit a tendency to follow strangers and, even more so, to take photographs without permission; adolescents with an average age of 11 show a heavy use of YouTube, TikTok, and Instagram. It is concluded that among digital risks in children and adults, the clusters highlight shared vulnerabilities, such as the addition of strangers and exposure to requests for personal data, which persist throughout the life stages but intensify in early adulthood. These findings emphasize the urgency of preventive policies addressing generational differences in social network use to promote proactive responses to digital harassment.
  • Institution Publication
    A Comparative Analysis of Early Fusion Architectures for Multimodal Gas Detection Using Machine Learning Models
    ( 2024-08-01)
    Arya G.
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    Bagwari A.
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    Agarwal S.
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    Aneja J.K.
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    Rodriguez C.
    Single-sensor gas detection models often lack robustness and accuracy, hindering safety and security. To enhance the accurate classification performance data from seven sensors along with thermal camera images has been used in this study, to train the model. The dataset focuses on four classes: Smoke, Perfume, No Gas and Mixture of Smoke and Perfume. Data from various sources capture different perspectives that enhance classification of the trained model, hence, early fusion technique was adopted to combine the extracted features, for an improved feature space. The sensor data undergoes preprocessing to normalize and remove noise. VGG16 model was used to extract image features. The fused data then acted as an input for the machine learning models for classification Among the tested models (SVM, Random Forest Classifier, and KNN), the Random Forest model achieved the best validation accuracy of 96.41%, outperforming SVM (94.22%) and KNN (94.53%). This approach demonstrates the effectiveness of multi-sensor data fusion for enhanced gas detection with high accuracy, potentially improving response times and reducing false alarms.
  • Institution Publication
    A comparative study of glide path instruments assessing flexibility and torsion by finite element method
    ( 2025-01-01)
    Rodríguez-Delgado I.
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    Daniela Bladé-Diaz A.
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    Reyes-Osorio L.A.
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    Jaime Flores-Treviño J.
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    Madla-Cruz E.
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    De La Garza-Ramos M.A.
    Background: This study presents a novel numerical evaluation of the bending and torsion behavior of four nickel- titanium glide path instruments, addressing a critical gap in understanding their mechanical performance under clinical conditions. Material and Methods: The evaluated instruments include the WaveOne Gold Glider with a parallelogram cross-section, the R-Pilot with an S-shaped cross-section, the ProGlider with a square cross-section, and the V Taper 2H with a triangular cross-section. Using advanced computer-aided design (CAD) software, detailed geometric models of each instrument were created, followed by numerical simulations performed in the SolidWorks finite element platform. Material properties of nickel-titanium alloys and boundary conditions were defined based on ISO 3630-1 specifications for bending and torsion tests. Results: The findings revealed significant variations in stress distribution and flexibility among the instruments. Notably, the R-Pilot demonstrated superior flexibility, being approximately 57% more flexible than the WaveOne Gold with a 28 mm deflection during bending. Conversely, the V Taper 2H exhibited the highest stress levels in bending tests. While torsional stress was comparable among V Taper 2H, ProGlider, and WaveOne Gold at approximately 500 MPa, R-Pilot showed the highest stress values under torsional loads. Additionally, distinct differences in stress distribution were observed between reciprocating and rotational glide paths. Conclusions: These insights underscore the necessity of evaluating both bending and torsion behaviors to optimize the design and clinical performance of glide path instruments.
  • Institution Publication
    A comprehensive 120-year assessment of drought dynamics and climate teleconnections in Odisha, India (1901–2020): insights from SPI and trend evaluation
    ( 2025-06-01)
    Guria R.
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    Dwivedi S.
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    Nayak P.
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    Goswami S.
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    da Silva R.M.
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    Santos C.A.G.
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    Santos C.A.G.
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    Dash P.C.
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    Mishra M.
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    Dogar M.M.
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    Meraj G.
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    Meraj G.
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    Almazroui M.
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    Almazroui M.
    Droughts have intensified in frequency and severity across South Asia, particularly impacting regions like Odisha, India, where agriculture remains highly dependent on monsoon rainfall. The objective of this study was to analyze drought dynamics and their relationship with climate teleconnections over a 120-year period (1901–2020) in Odisha, India. This study used Standardized Precipitation Index (SPI) at multiple timescales (SPI-3 to SPI-48), leveraging high-resolution gridded rainfall data. Long-term trends were evaluated using the Modified Mann–Kendall test and Sen’s slope estimator. Drought hotspots and spatial shifts were identified through Global Moran’s I and Local Indicators of Spatial Association (LISA). To understand climatic drivers, bivariate wavelet coherence analysis and Pearson correlation were applied between SPI-12 and major ocean-atmospheric teleconnection indices—ONI, IOD, SOI, and AMO. Findings reveal a spatial shift in drought severity from the eastern and southern regions in the early twentieth century to western and northwestern Odisha in recent decades. Decadal maps of drought characteristics (duration, severity, frequency, and intensity) show that districts such as Koraput, Nabarangpur, Nuapada, and Sundargarh experienced increasingly severe and frequent droughts since the 1970s. Strong coherence and correlation were observed between drought episodes and positive ONI and negative SOI/IOD phases, especially during significant drought years like 1965–66, 1974–75, 1987, 1999–2000, and 2009–2010. Spatial autocorrelation analysis confirmed clustering of drought-prone areas in western Odisha, while wavelet analysis highlighted dynamic, scale-specific linkages between SPI and teleconnection indices. These results underscore the non-linear and evolving nature of climate-drought interactions in Odisha. The study highlights the importance of integrating long-term drought diagnostics with teleconnection signals for proactive regional planning, improved early warning systems, and climate-adaptive policies. Graphic abstract: (Figure presented.)
  • Institution Publication
    A computer tool for Aiken's coefficients calculation: Applications in clinical and research settings
    ( 2025-03-01)
    Ventura-León J.
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    Lluncor-Vasquez A.
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    Chuquillanqui-Silva M.
    Rationale: In clinical and research settings, the validity and reliability of measurement instruments are crucial for reliable results. Current methods for computing validation metrics like Aiken's coefficients are often complex and error-prone, highlighting the need for a standardized computational tool to simplify and enhance this process. Aims and Objectives: The objective of this study was to develop AikenCalc, a tool created to automate the calculation of Aiken coefficients. This tool provides a quantitative method for examining the validity and reliability of consensus among expert judges. Method: AikenCalc was developed with Shiny app, an R library that allows an easy-to-use interface and improved computational efficiency. It was validated using a convergence method by comparing the manual calculations with those obtained using AikenCalc. Additionally, to examine usability and interface, six experts evaluated their experience using AikenCalc and provided improvement feedback. Results: AikenCalc demonstrated good convergent validity, closely aligning with the results obtained manually, and the six experts gave favorable ratings regarding the usability and interface of AikenCalc. Finally, it was shown that AikenCalc significantly reduced the time required for calculations, thanks to its user-friendly interface. Conclusion: AikenCalc represents a significant improvement in the validation of measurement instruments by automating and simplifying the calculation of Aiken's coefficients through a Shiny web application. Additionally, it fills a knowledge gap, as there is currently no similar calculator available in the field of research.
  • Institution Publication
    A conceptual architecture for AI-assisted Digital Twins in natural resource management
    ( 2026-03-01)
    Iglesias F.
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    Ros F.
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    Thuy L.H.V.
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    Gourcy L.
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    Moquet J.S.
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    Daële V.
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    Dupraz S.
    The management of natural resources is increasingly critical and challenging due to complex interactions among environmental, industrial, and societal processes. Traditional approaches often fail to integrate heterogeneous data, limiting predictive and decision-support capabilities. This study presents a conceptual architecture for an Artificial Intelligence (AI)-assisted Digital Twin (DT) of the Centre-Val de Loire region, designed to unify time-dependent multi-source data. Based on the ENVRI Reference Model, it covers Science, Information, Computational, Engineering, and Technology layers, defining standardized data exchange, communication protocols, and prototype functionalities. A proof of concept FIWARE implementation supports ingestion, monitoring and analytical services for piezometric and meteorological data, exemplified through groundwater dynamics in the Beauce aquifer. It integrates daily observations from 53 piezometric stations over more than five years, managing approximately 2.8 million records in a containerized environment. Results show that the proposed DT architecture can enhance sustainability-oriented decision making, integrating heterogeneous data and predictive analyses while enabling collaboration across scientific and technical domains. Its modular design offers a replicable template for future AI-assisted environmental DTs, scalable to larger regions. Hence, this work illustrates how DTs can improve environmental monitoring and understanding, providing a pathway toward resilient, data-driven management of natural resources.
  • Institution Publication
    A Cooperative Control Approach for Multi-quadrotor Formation in Agricultural Scenarios with Obstacles and External Disturbances
    ( 2025-01-01)
    Yanyachi P.R.
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    Canaza Ccari L.F.
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    Yanyachi D.
    This research aims to develop a robust cooperative control approach for the flight formation of multiple quadrotors in trajectory tracking tasks in agricultural scenarios with obstacles and external disturbances. For this purpose, a distributed autonomous control framework is proposed that integrates a guidance system and an advanced control system for each quadrotor under a leader-follower control scheme. The guidance system employs the Artificial Potential Field (APF) algorithm, which guarantees attraction to the target while avoiding obstacles. For the control system, a distributed consensus protocol based on an Adaptive Integral Fast Terminal Sliding Mode Control (AIFTSMC) is implemented, ensuring fast convergence and robust tracking of the reference trajectory, maintaining the alignment of the quadrotors throughout the entire flight mission. The validity of the proposed approach has been demonstrated through numerical simulations performed in Matlab/Simulink, implementing a representative agricultural scenario. The results show that the approach offers robust and efficient performance for multiple quadrotor flight formation in agricultural environments, even in the presence of external disturbances and obstacles.
  • Institution Publication
    A Country of Provinces or Non-Metropolitan Cities? COVID-19 as a Case Study to Understand the Dynamics of Cities in Peru
    ( 2024-02-01)
    Rojas-Quiroz J.
    While the literature does not define a single way of identifying and delimiting cities, one of the most widely accepted methodologies is to combine morphological and functional criteria, leaving aside administrative boundaries. In Peru, these boundaries are ordered from smallest to largest by districts, provinces and regions, and both academia and public institutions in charge of generating data and/or analyzing cities assume that all cities outside the capital, Lima and Callao, can be treated as provinces or regions. In parallel, since the emergence of the COVID-19 pandemic, several studies have shown that it is a phenomenon affected by socioeconomic factors widely studied in urban settings. In this regard, this research aims to use COVID-19 mortality data to compare the situation in ninety Peruvian cities and the provinces to which they belong. Its usefulness lies in evaluating the importance of a proper definition of non-metropolitan cities in Peru to open the way for a discussion on the generation of data on them and the consequent adaptation of existing urban planning and management policies. The results show that in most of the cities analyzed, the mortality rate is higher than that of the province to which they belong, and that the conditions of the capital city may be overestimated when carrying out analyses that do not consider a proper definition of the rest of the country's cities.
  • Institution Publication
    A critical exploration of stigma interventions and programs for queer peoples across the life course in Canada: a scoping review protocol
    ( 2025-12-01)
    Sinno J.
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    Logan J.
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    Carliner J.
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    Perez-Brumer A.
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    Logie C.
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    Logie C.
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    Logie C.
    ;
    Grace D.
    Background: Queer populations (sexual and gender diverse people, including two-spirit, lesbian, gay, bisexual, trans, and queer) in Canada face significant health disparities, largely driven by stigma related to sexual and gender identities. These inequities are associated with adverse health outcomes. Although a growing body of literature examines stigma reduction, interventions often focus on specific types of queer stigma rather than considering the broader, intersectional experiences of queer people. This scoping review aims to critically explore the current state of queer stigma across the life course in Canada, with an emphasis on understanding their impact, successes, and gaps. Methods: This review will include studies that address interventions aimed at reducing queer-related stigma in Canada. Eligible studies must focus on queer populations and measure outcomes related to stigma reduction. Studies of any design (qualitative, quantitative, mixed methods), published in English or French, and from any year will be considered. A systematic search will be conducted across multiple databases, including Medline-R (Ovid), Embase (Ovid), APA PsycInfo (Ovid), CINAHL (EBSCO), Social Services Abstracts (ProQuest), Social Science Abstracts (ProQuest), and Social Science Citation Index (Web of Science), along with grey literature sources. Two reviewers will independently assess potential articles against the inclusion criteria through two stages: titles and abstracts as well as full-text screening. Data extraction will focus on study characteristics, intervention details, and outcomes related to stigma reduction. Findings will be reported in tables and narrative summaries, guided by the socioecological model and intersectional queer theories. Data will be analyzed to identify trends and gaps in current interventions aimed at addressing queer stigma. Discussion: Using an intersectional queer approach and the socioecological model, this review will identify gaps and strengths in queer stigma programming and interventions across the life course. The broad inclusion criteria and a rigorous approach will account for academic and grey literature, highlighting ongoing treatments, measurement tools, and resources. This extensive data collection will inform future research on queer peoples’ resource and programming needs in Canada. Findings will contribute to workshops development, training modules, and community reports for healthcare providers and community organizations serving queer communities. Systematic review registration: https://doi.org/10.6084/m9.figshare.28523621.v1.
  • Institution Publication
    A Cryotrap Membrane Introduction Mass Spectrometry System for Analysis of Volatile Organic Compounds in Water at the Low Parts-per-Trillion Level
    ( 1996-10-01)
    Mendes M.
    ;
    Pimpim R.
    ;
    Kotiaho T.
    ;
    Kotiaho T.
    ;
    Eberlin M.
    Detection of volatile organic compounds (VOCs) in aqueous solution at low parts-per-trillion (ppt) levels is accomplished using a very simple and efficient on-line preconcentration cryotrap membrane introduction mass spectrometry (CT-MIMS) system. The conventional MIMS probe is modified so that the membrane interface is placed about 15 cm away from the ion source. A U-shaped trap tube is then inserted between the membrane interface and the ion source. Cryotrapping is performed with liquid nitrogen for 15 min, followed by fast heating at ∼15°C s-1, which thermally releases the condensed VOCs almost at once into the ion source region of a quadrupole mass spectrometer. By applying electron ionization and a selective ion monitoring scan mode, a very sharp and intense peak is obtained. The performance of the CT-MIMS system was compared with that of conventional MIMS, and after reaching the best conditions for the trapping and heating cycles, an improvement factor in signal intensity of about 100 was observed for a series of VOCs. The extraordinary sensitivity of CT-MIMS system allows VOCs to be detected at very low concentrations, detection limits being typically on the order of 10-20 ppt. The results also show excellent linearity and reproducibility for the system.